Derek Tan: Publications

Read up on the latest publications in diversity-oriented synthesis, rational drug design, chemical biology, and drug discovery research from the Tan Lab!


View: Selected Publications | Complete Publications

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.

  1. Activation of N-formyldipeptide-masked prodrugs by human peptide deformylase.
    Geißen, R.; Yildirim, O.; Köhn, M.; Scheinberg, D. A.; Tan, D. S.* ACS Chem. Biol. 2025, 2171–2179.
    [ Abstract | PubMed | PMC ]

  2. Structural basis for transthiolation intermediates in the ubiquitin pathway.
    Kochańczyk, T.; Hann, Z. S.; Lux, M. C.; Delos Reyes, A. M. V.; Ji, C.; Tan, D. S.* ; Lima, C. D.* Nature 2024, 633, 216–223.
    [ Abstract | PubMed | PMC ]

  3. Engineering CAR-T cells to activate small-molecule drugs in situ.
    Gardner, T. J.; Lee, J. P.; Bourne, C. M.; Wijewarnasuriya, D.; Kinarivala, N.; Kurtz, K. G.; Corless, B. C.; Dacek, M. M.; Chang, A. Y.; Mo, G.; Nguyen, K. M.; Brentjens, R. J.; Tan, D. S.*; Scheinberg, D. A*. Nat. Chem. Biol. 2022, 18, 216–225.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Nat. Chem. Biol.)

  4. Cheminformatic analysis of natural product-based drugs and chemical probes.
    Stone, S.; Newman, D. J.; Colletti, S. L.; Tan, D. S.* Nat. Prod. Rep. 2022, 39, 20–32.
    [ Abstract | PubMed | PMC ]

  5. Defining new chemical space for drug penetration into Gram-negative bacteria.
    Zhao, S.; Adamiak, J. W.; Bonifay, V.; Mehla, J.; Zgurskaya, H. I.; Tan, D. S.* Nat Chem Biol 2020, 16, 1293–1302.
    [ Abstract | PubMed | PMC ]

  6. Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
    Lux, M. C.; Standke, L. C.; Tan, D. S.* J. Antibiot. 2019, 72, 325–349.
    [ Abstract | PubMed | PMC ]

  7. Structure-based design, synthesis, and biological evaluation of non-acyl sulfamate inhibitors of the adenylate-forming enzyme MenE.
    Evans, C. E.†; Si, Y.†; Matarlo, J. S.; Yin, Y.; French, J. B.; Tonge, P. J.*; Tan, D. S.* Biochemistry 2019, 58, 1918–1930.
    [ Abstract | PubMed | PMC ]

  8. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
    Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
    [ Abstract | PubMed | PMC ]
    (Highlighted in ACS Chem. Biol.)

  9. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    [ Abstract | PubMed | PMC ]

  10. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    [ Abstract | PubMed | PMC ]
    (Highlighted in SciBX )

  11. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    [ Abstract | PubMed | PMC ]

  12. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

  13. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    [ Abstract | PubMed | PMC ]
    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )