Memorial Hospital Research Laboratories

The Simon Powell Lab

Research

Simon N. Powell, MD, PhD
Simon N. Powell, MD, PhD


Professor

The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically. 

View Lab Overview

Publications Highlights

Ahmed-Seghir, S. et al. A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells. Elife 12, (2023)

Setton, J. et al. Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature 621, 129–137 (2023)

Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)

Moore, G. et al. Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer. Mol. Cancer Res. 20, 1061–1070 (2022)

Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)

View All Publications

People

Simon N. Powell, MD, PhD

Simon N. Powell, MD, PhD



Professor

  • Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.
  • PhD, MD, University of London
powells@mskcc.org
Email Address
View physician profile
Physician profile

Members

Erika Buechelmaier
Weill-Cornell Graduate Student
Research Technician
Manisha Jalan
Research Scholar
Niamh McDermott
Research Fellow
Resident
Jeremy Setton
Assistant Member L1
Robert Delsite, PhD
Senior Research Scientist
Simon Powell, MD, PhD
Chairman Attending
Sena Ahmed-Seghir
Research Scholar
Research Fellow
Research Technician
Gesa Junge
Research Fellow
Kyrie Olsen
Research Technician
Isabella Pecorari
Research Technician
Research Fellow
Shyamal Subramanyam
Research Fellow
Graduate Research Assistant
Research Technician
Graduate Student
Research Fellow
Research Fellow
Research Technician
Graduate Research Assistant
Research Fellow
Research Fellow

Lab News & Events

Upcoming event

Mechanism for Repair of Chromosome Breaks

Memorial Sloan Kettering Cancer Center
1275 York Avenue
Room M-107
New York, NY 10065

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Join the Powell Lab: Postdoctoral Opportunities in Cancer Biology at Memorial Sloan Kettering Cancer Center, NYC

The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists to lead multidisciplinary projects at the interface of DNA repair and translational cancer research.

Apply now

Get in Touch

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Simon N. Powell discloses the following relationships and financial interests:

  • AstraZeneca
    Professional Services and Activities
  • Cancer Research UK
    Professional Services and Activities
  • PharmaPier US LLC
    Professional Services and Activities (Uncompensated)
  • Shandong Cancer Hospital
    Professional Services and Activities (Uncompensated)
  • Varian Medical Systems
    Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


View all disclosures