The Simon Powell Lab
Research
Professor
The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically.
Featured News
Publications Highlights
Ahmed-Seghir, S. et al. A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells. Elife 12, (2023)
Setton, J. et al. Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers. Nature 621, 129–137 (2023)
Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)
Moore, G. et al. Templated Insertions Are Associated Specifically with BRCA2 Deficiency and Overall Survival in Advanced Ovarian Cancer. Mol. Cancer Res. 20, 1061–1070 (2022)
Anand, R. et al. HELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51. Nature 601, 268–273 (2022)
People
Simon N. Powell, MD, PhD
Professor
- Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.
 - PhD, MD, University of London
 
- powells@mskcc.org
 - Email Address
 - View physician profile
 - Physician profile
 
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                    Lab News & Events
Upcoming event
Mechanism for Repair of Chromosome Breaks
Memorial Sloan Kettering Cancer Center
1275 York Avenue
Room M-107
New York, NY 10065
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Join the Powell Lab: Postdoctoral Opportunities in Cancer Biology at Memorial Sloan Kettering Cancer Center, NYC
The Powell Lab at Memorial Sloan Kettering Cancer Center is seeking enthusiastic postdoctoral scientists to lead multidisciplinary projects at the interface of DNA repair and translational cancer research.
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Disclosures
Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.
MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.
Simon N. Powell discloses the following relationships and financial interests:
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                          AstraZeneca
Professional Services and Activities - 
                          Cancer Research UK
Professional Services and Activities - 
                          PharmaPier US LLC
Professional Services and Activities (Uncompensated) 
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                          Shandong Cancer Hospital
Professional Services and Activities (Uncompensated) - 
                          Varian Medical Systems
Professional Services and Activities 
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.