
How the brain develops and what goes wrong in complex developmental disorders remain largely unexplored, in part because of the lack of models that accurately represent these complex processes. In our lab, we have created organoids that faithfully recapitulate human brain development. In particular, I study outer radial glia, a type of glial cell only present in humans and a few other gyrencephalic mammals. By understanding what types of neurons outer radial glia give rise to and how outer radial glia are formed, we can better understand what goes wrong in complex developmental disorders. Our ultimate goal is to develop treatments for these disorders in the future.