The Christina Gladkova Lab

The Gladkova lab aims to uncover the principles that govern the shape, distribution and movement of organelles, with the ultimate goal of understanding how organelle architecture supports cellular function. This is essential, because defects in organelle maintenance cause neurodegeneration, and altered organelle architecture is a hallmark of many diseases including cancer.

To discover the mechanisms and signals that control organelle architecture, we reduce cellular complexity by building synthetic organelle probes in living cells. These isolate specific organelle behaviours, for example mitochondrial microtubule-based transport. We combine this in-cell reconstitution approach with traditional reconstitution methods (biochemistry, structural biology) and microscopy to study native organelles across different physiological contexts.

Learn more about the science: https://gladkovalab.com